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. 2011 Sep 14;6:1963–1975. doi: 10.2147/IJN.S22731

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© 2011 Talaei et al, publisher and licensee Dove Medical Press Ltd.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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Percentage release of ASOND and doxorubicin from 5 mg of drug-loaded nanoparticles during 15 hours in PBS and cytosol simulated medium using DTT. (A) Percentage release of ASOND, (B) Percentage release of doxorubicin. The release data are mean ± SD for each formulation at different time points indicated (n = 4).

Abbreviations: ASOND, antisense oligonucleotide; DOX, doxorubicin; NAC-C, N-acetyl cysteine-chitosan; NAP-C, N-acetyl penicillamine-chitosan; LMWC, low-molecular- weight chitosan; RPMI, Roswell Park Memorial Institute medium; FBS, fetal bovine serum; PBS, phosphate buffered saline; DTT, threo-1,4-dimercapto-2,3- butandiol; SD, standard deviation.