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Cytotoxicity of DTIC, DR5 mAb, DTIC-NPs, DTIC-NPs + DR5 mAb, and DTIC-NPs-DR5 mAb in A375 cells and NIH cells. The cells were incubated using different concentrations of DTIC, DR5 mAb, DTIC-NPs, NPs-DR5 mAb, DTIC-NPs + DR5 mAb and DTIC-NPs – DR5 mAb (contain the same DTIC) for a time period of 72 hours (mean ± standard deviation; n = 5).
Notes: *P < 0.05; **P < 0.01; ***P < 0.001.
Abbreviations: DTIC, dacarbazine; mAb, monoclonal antibody; NPs, nanoparticles.
