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. Author manuscript; available in PMC: 2011 Sep 27.
Published in final edited form as: Biochim Biophys Acta. 2010 Mar 6;1804(6):1376–1384. doi: 10.1016/j.bbapap.2010.02.014

Figure 7.

Figure 7

Diagrammatic representations for the differential influence of Qds+ and polylysine on the microenvironment of the active site pocket of hCA XII. It is surmised that unlike polylysine, the binding of Qds+ to hCA XII alters the microenvironment of the enzyme’s active site pocket, resulting in reorientation of the Zn2+-ligated DNSA and thus overcoming the inhibitory effect of DNSA. Since such changes are not manifested upon binding of polylysine to hCA XII (DNSA) complex and thus the enzyme remains inhibited.