Fig. 5.
Effect of repeated depolarization on sodium current stability and modification by tefluthrin of Nav1.7 sodium channels. (A) Effect of repeated depolarizing pulses on the normalized amplitude of peak transient sodium currents measured in the absence or presence of tefluthrin (100 µM); values were normalized to the amplitude of the peak current from the same oocyte prior to repetitive depolarization and are expressed as means of 14 paired experiments with different oocytes; in all cases SE values were smaller than the data point symbols. (B) Effect of repeated depolarizing pulses on the extent of tefluthrin modification of Nav1.7 channels; values for fractional modification were calculated from the normalized conductances of sodium tail currents and are expressed as means of 6 separate experiments with different oocytes; bars show SE values larger than the data point symbols.