Fig. 3.
RTL1000 treatment 4 h after the onset of ischemia reduces infarct volume in DR2 transgenic mice. Sixty-minute transient MCAO was followed by four daily treatments with vehicle (Tris-HCl) or 100 µg RTL, and infarction volume was quantified as a percentage of the non-ischemic contralateral hemisphere. Quantification of infarct volume of vehicle- and RTL551-treated mice. Group sizes were n=10 for vehicle and n=10 for RTL1000. Data are presented as mean±SEM of individual mice. *Different than vehicle, P<0.05