Skip to main content
. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Reprod Toxicol. 2011 May 20;32(1):33–42. doi: 10.1016/j.reprotox.2011.05.008

Table 4.

21-day and 50-day (mean ± SD) uterine morphometric data.

Treatment group Luminal epithelial (LE) cell height (μm) (n = 200 values/group) Stromal thickness (μm) (n = 140–180 values/group) Myometrial thickness (μm) (n = 140–180 values/group) Glandular circumference (μm) (n = 162–181 values/group) Gland count in 200× field (n = 40 values/group)
Control (21) 13.6 ± 1.9 173.4 ± 55.9 123.2 ± 28.5 109.7 ± 18.5 14.4 ± 4.4
S-(−)equol (21) 13.5 ± 1.6 213.8 ± 67.0c 123.1 ± 38.9 116.6 ± 18.6b 12.2 ± 3.9d
R-(+)equol (21) 14.0 ± 1.8a 227.5 ± 63.3c 136.4 ± 32.3c 115.2 ± 17.7a 13.7 ± 5.0
Control (50) 20.0 ± 3.3 620.7 ± 169 305.6 ± 88 169.3 ± 31 21.8 ± 7.6
S-(−)equol (50) 21.2 ± 4.2b 690.1 ± 187c 310.0 ± 91 173.0 ± 29 23.2 ± 7.2
R-(+)equol (50) 19.9 ± 2.8 662.0 ± 187d 280.9 ± 78a 173.8 ± 30 22.3 ± 6.8
a

p ≤ 0.02 R-(+)equol increased LE height and gland circumference, reduced myometrium compared to control.

b

p ≤ 0.004 S-(+)equol increased LE height and gland circumference compared to controls.

c

p < 0.0001 S-(−)equol/R-(+)equol treated pups had greater stromal or myometrial thickness than control pups.

d

p ≤ 0.05 R-(+)equol greater stromal thickness, S-(−)equol lower uterine gland count than control pups.