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. Author manuscript; available in PMC: 2011 Sep 27.
Published in final edited form as: Exp Mol Med. 2007 Dec 31;39(6):679–689. doi: 10.1038/emm.2007.74

Figure 2.

Figure 2

Employment of Ii for stable presentation of a desired antigenic peptide by DCs. The translated Ii-antigen peptide enters the ER and binds to an MHC class II molecule, with the antigenic peptide occupying the peptide-binding groove of the MHC molecule. In the lysosomal compartments, the Ii chain is degraded, leaving the desired antigenic peptide in the peptide-binding groove of the MHC class II molecule and allowing for the stable presentation of the antigenic peptide on the cell surface.