Table 3.
Cytokine levels in serum from HIV-1-uninfected and HIV-1-infected CSWs, and HIV-1-uninfected non-CSW control subjects
| HIV-1-uninfected CSWs | HIV-1-infected CSWs | HIV-1-uninfected non-CSW controls | P-valuea | |
|---|---|---|---|---|
| N=51 | N=51 | N=68 | ||
| IL-2 | 5.7 (19.3) | 0.9 (2.5)b | 2.9 (5.1) | 0.02 |
| IL-4 | 1.8 (4.2)c | 0.5 (1.1) | 0.5 (1.8) | 0.002 |
| IL-6 | 4.1 (9.4) | 2.9 (3.7) | 2.2 (4.2) | NS |
| IL-10 | 5.5 (11.4) | 2.4 (5.5)d | 3.7 (4.7) | 0.05 |
| TNF-α | 3.2 (9.2) | 0.5 (1.5)e | 1.7 (2.7) | 0.021 |
| IFN-γ | 0.6 (4.6) | 1.7 (8.7) | 0.5 (2.2) | NS |
CSW, commercial sex worker; HIV-1, human immunodeficiency virus type 1; IFN, interferon; IL, interleukin; N, number of participants; NS, nonsignificant; TNF, tumor necrosis factor.
Data are mean (s.d.) pg ml−1.
The lower detection limit for each assay was 2.6 pg ml−1 for IL-2 and IL-4, 3.0 pg ml−1 for IL-6, 2.8 pg ml−1 for IL-10 and TNF-α, and 7.1 pg ml−1 for IFN-γ.
P-values for the comparison across all groups were calculated with one-way analysis of variance test.
P=0.010 for the comparison between HIV-1-infected CSWs and HIV-1-uninfected CSWs, and P=0.012 for the comparison between HIV-1-infected CSWs and HIV-1-uninfected non-CSWs as determined by Mann–Whitney U-test.
P=0.016 for the comparison between HIV-1-uninfected CSWs and HIV-1-infected CSWs, and P=0.002 for the comparison between HIV-1-uninfected CSWs and HIV-1-uninfected non-CSWs as determined by Mann–Whitney U-test.
P=0.028 for the comparison between HIV-1-infected CSWs and HIV-1-uninfected CSWs, and P=0.028 for the comparison between HIV-1-infected CSWs and HIV-1-uninfected non-CSWs as determined by Mann–Whitney U-test.
P=0.019 for the comparison between HIV-1-infected CSWs and HIV-1-uninfected CSWs, and P=0.007 for the comparison between HIV-1-infected CSWs and HIV-1-uninfected non-CSWs as determined by Mann–Whitney U-test.