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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Neurobiol Aging. 2011 Apr 22;33(8):1507–1521. doi: 10.1016/j.neurobiolaging.2011.03.001

Figure 3. OVX induced increase in oxidative stress and prevention by 17β-estradiol.

Figure 3

Brain mitochondria were isolated and serum samples were collected from Sham-OVX, OVX, OVX+E2 groups of both nonTg and 3xTg-AD mice. Lipid peroxide levels were determined by the leucomethylene blue assay. Serum 8-oxoGuanine levels were determined with the 8-oxoGuanine assay kit. A, OVX induced increased in mitochondrial lipid peroxidation and prevention by 17β-estradiol; B, OVX induced increased in hippocampal lipid peroxidation and prevention by 17β-estradiol; C, OVX induced significant increase in serum 8-oxoGuanine level and prevention by 17β-estradiol. Bars represent mean value ± S.E.M. (*, P<0.05 compared to nonTg OVX group; #, P<0.05 compared to3xTgAD OVX group, n=7)