Protein profiles across fibrosis grades showing the top candidates at discriminating grade 3 from grade 4, with DIGE (left) and iTRAQ (right). Proteins shown: DIGE spots 471 (kininogen-1, clusterin, complement C3, haptoglobin) and 468 (complement factor H, haptoglobin, serum amyloid P-component); iTRAQ proteins 13 (vitamin D-binding protein), 127 (coagulation factor IX), 12 (inter-alpha-trypsin inhibitor heavy chain H4), and 80 (complement component 1, q subcomponent, gamma polypeptide). Vertical bars indicate 95% confidence intervals