Figure 1. Tissue-specific proteins tend to interact with commonly expressed proteins.

A. Tissue-specific protein interaction networks for the 10 main human tissues. B. The relationship between protein expression specificity and protein interaction degree (Peripheral-A: degree  = 1; Peripheral-B: 20> degree >1; Hub: 100> degree ≥20; Super-hub: degree ≥100), right upper: Distribution of hub and super-hub proteins in different protein subunits. C. The degree densities of intra-subunit of tissue-specific proteins and between tissue-specific subunit and other protein subunits (***1-3 versus 10, p<0.001).