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. 2011 Sep 27;6(9):e25639. doi: 10.1371/journal.pone.0025639

Figure 2. The endogenous neurotransmitter, dopamine (DA), in the presence of raclopride (RAC), a D2R antagonist, induced LTP mediated through D1/5R activation.

Figure 2

Responses are plotted as percent change of baseline fEPSPs as a function of time. Numbers on the representative traces show the time on the graph at which they were recorded. A) DA in the presence of RAC (clear triangles, 146.5±3.2%, *p<0.05, n = 5) shows potentiation similar to that recorded with SKF81297 (Figure 1B) in amygdala slices from cocaine CPP animals while the saline-treated group (clear circles, 102.2±2.4%, ns, n = 5) exhibits no LTP. B) DA+RAC-induced LTP is abolished by SCH23390 in the cocaine CPP group (filled triangles, 94.5±4.5%, ns, n = 6). For comparison panels A and B use same data graphs and fEPSP traces for the slices from cocaine CPP group superfused with SKF81297.