Skip to main content
. 2011 Sep 27;6(9):e25587. doi: 10.1371/journal.pone.0025587

Figure 1. Design of the studies.

Figure 1

Hepatic steatosis was induced by placing C57BL/6 mice on a 60% high fat diet for 9 weeks, followed by a two or four week treatment period with either Marimastat (MAR) or methylcellulose vehicle (VEH) twice daily (A). Leptin deficient ob/ob animals were placed on a 10% standard fat diet for two weeks, followed by a four week treatment period with either MAR or VEH twice daily (B). The efficacy of Marimastat on post-operative outcome following reversal of steatosis was evaluated in a model of two-thirds hepatectomy (C). C57BL/6 mice were placed on a 60% high fat diet, followed by two weeks of treatment with MAR or VEH twice daily. Mice were then subjected to a two-thirds hepatectomy, and sacrificed postoperatively to assess hepatic injury.