Figure 2. Marimastat treatment resulted in decreased adiposity and liver weights and normalized macroscopic appearance of the liver.

Body weight loss was calculated relative to the weight of each individual animal before initiation of the experiment (A). As a measure of adiposity, white adipose tissue fat-index was calculated using the sum of the individual fat pads as a percentage of the eviscerated body weight (B). Liver to body weight ratios were calculated (C). Macroscopic appearance of livers from C57BL/6 and ob/ob mice at time of sacrifice (D). Values represent the mean ± SEM. Statistical significance is calculated between the VEH and MAR animals (n = 5 C57BL/6 and n = 4 ob/ob animals per group; *, P<0.05; **, P<0.01).