Skip to main content
. 2011 Sep 27;6(9):e25587. doi: 10.1371/journal.pone.0025587

Figure 7. Reversal of established steatosis using Marimastat ameliorated post-operative liver injury, without affecting regeneration.

Figure 7

C57BL/6 animals were fed a high fat diet for 9 weeks, followed by two weeks of treatment with either Marimastat (MAR) or vehicle (VEH) control. After reversal of steatosis (A), animals were subjected to a two-thirds hepatectomy. Marimastat did not affect speed of liver regeneration, as measured by liver to body weight ratios over time (B). Post-operative liver injury was significantly decreased in diet-induced obese animals that had their steatosis reversed following Marimastat treatment, as quantified by aspartate aminotransferase (AST; C) and alanine aminotransferase (ALT; D). Values represent the mean ± SEM. Statistical significance is calculated between the VEH and MAR animals (n = 10 animals per group per time point; *, P<0.05; **, P<0.01; ***, P<0.001).