Figure 6.

Representative images of HIF-1α staining in noninfected (A), PbK-infected (B), and PbA-infected (C) mice. Diverse expression in several cell types was observed in patches (D), and pronounced perivascular labeling of neurons was demonstrated in PbA mice (E and F). F: Nuclei are blue, vessels are green, and HIF-1α–positive cells are red. Scale bars: 100 μm (A–C); 50 μm (D–F). Quantifications are visualized in stripcharts for each quantitative trait: G: Endothelial cells. H: Intravascular staining. I: Neurons. J: Glial cells. Horizontal bar indicates the mean, and vertical bars indicate SD. *0.05 > P > 0.01 using the Wilcoxon rank test.