Table 1.
Inhibitory Effect of Poloxin on Proliferation in Various Cell Lines
| Cells/cell lines | Tissue type | EC50 (μmol/L) |
|---|---|---|
| Tumor | ||
| MCF7 | Breast | 35 |
| MDA-MB-231 | Breast | 15 |
| Detroit 562 | Pharynx | 15 |
| T47D | Breast | 25 |
| A549 | Lung | 20 |
| SW 480 | Colon | 22 |
| HCT 116 | Colon | 25 |
| HeLa | Cervix | 25 |
| HeLa P25⁎ | Cervix | 22 |
| HeLa 776–6† | Cervix | 22 |
| PC-3 | Prostate | 20 |
| Normal | ||
| hTERT-RPE1 | Retinal epithelial | 20 |
| MTSV-1 | Mammary epithelial | 20 |
| Fibroblasts | Foreskin fibroblastic | 25 |
| HUVECs | Umbilical vein endothelial | 20 |
HUVEC, human umbilical vein endothelial cell.
⁎
Stably Plk1-depleted HeLa.
†
Stably cyclin B1–depleted HeLa.