Table 2.
Relationship between Twist1 Expression of 195 Gastric Cancers and Various Clinicopathologic Factors
| Characteristic | Total | Twist1 expression in cancer cells |
Twist1 expression in cancer associated fibroblasts |
||||
|---|---|---|---|---|---|---|---|
| Negative, no. (%) | Positive, no. (%) | P value | Negative, no. (%) | Positive, no. (%) | P value | ||
| Age, years | |||||||
| <60 | 87 | 62 (71.3) | 25 (28.7) | 0.891 | 24 (27.6) | 63 (72.4) | 0.794 |
| ≥60 | 108 | 76 (70.1) | 32 (29.6) | 28 (25.9) | 80 (74.1) | ||
| Sex | |||||||
| Female | 122 | 86 (70.5) | 36 (29.5) | 0.912 | 30 (24.6) | 92 (75.4) | 0.397 |
| Male | 73 | 52 (71.2) | 21 (28.8) | 22 (30.1) | 51 (69.9) | ||
| Size, cm | |||||||
| <5 | 86 | 70 (81.4) | 16 (18.6) | 0.004 | 34 (39.5) | 52 (60.5) | <0.001 |
| ≥5 | 109 | 68 (62.4) | 41 (37.6) | 18 (16.5) | 91 (83.5) | ||
| Differentiation | |||||||
| WD | 37 | 34 (91.9) | 3 (8.1) | 0.007 | 12 (32.4) | 25 (67.6) | 0.263 |
| MD | 63 | 42 (66.7) | 21 (33.3) | 15 (23.8) | 48 (76.2) | ||
| PD | 63 | 38 (60.3) | 25 (39.7) | 13 (20.6) | 50 (79.4) | ||
| Other types⁎ | 32 | 24 (75.0) | 8 (25.0) | 12 (37.5) | 20 (62.5) | ||
| Lauren classification | |||||||
| Intestine | 100 | 76 (76.0)) | 24 (24.0) | 0.099 | 26 (26.0) | 74 (74.0) | 0.829 |
| Mixed or diffuse | 95 | 62 (65.3) | 33 (34.7) | 26 (27.4) | 69 (72.6) | ||
| pT classification | |||||||
| T1-T2 | 90 | 67 (74.4) | 23 (25.6) | 0.296 | 34 (37.8) | 56 (62.2) | 0.001 |
| T3-T4 | 105 | 71 (67.6) | 34 (33.4) | 18 (17.1) | 87 (82.9) | ||
| Lymph node metastasis | |||||||
| Negative | 71 | 60 (84.5) | 11 (15.5) | 0.001 | 32 (45.1) | 39 (54.9) | <0.001 |
| Positive | 124 | 78 (62.9) | 46 (37.1) | 20 (16.1) | 104 (83.9) | ||
MD, moderately differentiated; PD, poorly differentiated; WD, well differentiated.
⁎
Other types included signet ring cell carcinoma and mucinous carcinoma.