Table 1.
Clinical and Immunohistochemical Characteristics of 44 Human Pituitary Adenomas
| Clinical diagnosis | Immunohistochemical status⁎ |
||||||
|---|---|---|---|---|---|---|---|
| FSH | LH | TSH | α-Subunit | PRL | GH | ACTH | |
| Nonfunctioning adenoma | |||||||
| 1 | rare | − | rare | rare | − | − | 1+ |
| 2 | − | − | − | − | − | − | − |
| 3 | rare | − | − | rare | − | − | − |
| 4 | 3+ | − | − | 1+ | rare | − | − |
| 5 | 3+ | 4+ | 3+ | 1+ | − | − | − |
| 6 | 1+ | rare | rare | − | − | − | − |
| 7 | rare | − | − | rare | − | − | − |
| 8 | − | − | − | − | − | rare | − |
| 9 | − | rare | − | − | − | − | − |
| 10 | − | − | rare | − | − | − | rare |
| 11 | 3+ | 4+ | 4+ | rare | rare | − | − |
| 12 | 2+ | 3+ | 1+ | 1+ | rare | − | − |
| 13 | 1+ | 1+ | 1+ | rare | rare | rare | − |
| 14 | rare | 2+ | 1+ | − | rare | − | − |
| 15 | 1+ | rare | − | − | rare | − | − |
| 16 | 1+ | 1+ | 1+ | rare | − | − | − |
| 17 | 1+ | rare | 1+ | 1+ | − | − | − |
| 18 | 4+ | 4+ | − | rare | rare | − | − |
| 19 | rare | − | rare | rare | rare | − | rare |
| 20 | 1+ | 1+ | 1+ | 1+ | rare | − | − |
| 21 | 3+ | 3+ | 1+ | rare | 1+ | − | − |
| 22 | 1+ | 1+ | 1+ | 1+ | 1+ | − | − |
| 23 | − | − | − | − | rare | 1+ | − |
| 24 | − | − | − | − | − | − | − |
| 25 | − | − | − | − | − | − | − |
| Acromegaly | |||||||
| 26 | ND | ND | ND | − | rare | 3+ | ND |
| 27 | rare | 1+ | − | − | 2+ | 3+ | 1+ |
| 28 | − | − | − | − | 3+ | 4+ | − |
| 29 | rare | rare | 3+ | 3+ | rare | 4+ | − |
| 30 | ND | ND | ND | 2+ | 2+ | 4+ | ND |
| 31 | ND | ND | ND | − | ND | 4+ | ND |
| 32 | ND | ND | ND | ND | 2+ | 3+ | ND |
| Prolactinoma | |||||||
| 33 | − | − | − | − | 4+ | 2+ | − |
| 34 | − | − | − | − | 4+ | 2+ | − |
| 35 | − | − | − | − | 4+ | − | − |
| 36 | − | − | − | − | 4+ | − | − |
| 37 | − | − | − | − | 4+ | − | − |
| Cushing's disease | |||||||
| 38 | rare | − | − | − | − | − | 4+ |
| 39 | ND | ND | ND | ND | − | ND | 4+ |
| 40 | ND | ND | ND | − | − | ND | 4+ |
| 41 | − | − | − | − | − | − | 4+ |
| 42 | ND | ND | ND | ND | rare | ND | 4+ |
| 43 | − | − | − | 1+ | rare | − | 4+ |
| 44 | − | − | − | − | 1+ | − | 4+ |
ACTH, adrenocorticotropic hormone; FSH, follicle-stimulating hormone; GH, somatotropin (growth hormone); LH, luteinizing hormone; PRL, prolactin; TSH, thyrotropin (thyroid-stimulating hormone); α-subunit of glycoprotein hormones.
⁎
Immunostaining was graded by the number of positive cells: −, negative; rare, only a few cells are positive; 1+, 1% to 5% positivity; 2+, 6% to 20% positivity; 3+, 21% to 50% positivity; 4+, >50% positivity; ND, not done (staining was not performed).