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. 2011 Oct;179(4):1917–1928. doi: 10.1016/j.ajpath.2011.06.029

Figure 4.

Figure 4

IFNγ increases T cells and decreases neutrophils within lesions of murine Lyme carditis. Wild-type and IFNγ-deficient mice were infected with B. burgdorferi N40 or inoculated with BSK medium as uninfected controls. Hearts were collected at 14 and 25 days after infection, divided into sections, and stained with fluorescent antibodies against CD3 or both Gr-1 and F4/80 concurrently. Results show the mean ± SD total number of cells in 10 fields (×630) expressing CD3 (A), Gr-1 (B), F4/80 (C), or both Gr-1 and F4/80 (D). There was no difference between controls at 14 and 25 days after infection, so data from the two time points were combined. Uninfected groups, n = 8 from two independent experiments; 14-day groups, n = 5 from one experiment; 25-day groups, n = 10 or 11 from two experiments. *P < 0.001 versus wild-type at the same time point.