Figure 1.

Jnk1^−/− mice are resistant to CIA, whereas Jnk2^−/− mice are highly susceptible. A: Clinical arthritis scores. B: Cumulative incidence of arthritis in wt, Jnk1^−/−, and Jnk2^−/− mice with CIA. The severity of arthritis was evaluated using a scoring system, as described in Materials and Methods. Results are presented as the mean ± SD. *P < 0.05 (n = 20 for Jnk1^−/−, n = 10 for Jnk2^−/−, and n = 15 for wt).