Figure 2.

Histological analysis confirms the lack of inflammation in joints from Jnk1^−/− mice with CIA. A: Representative H&E-stained sections from hind paws of wt, Jnk1^−/−, and Jnk2^−/− mice obtained at day 70 after immunization. There was absent or minimal inflammation in the Jnk1^−/− section. B: The severity of arthritis was histologically evaluated using the following parameters: bone destruction, hyperplasia of the synovium, and infiltration of monomorphonuclear and polymorphonuclear cells. Each parameter was scored as described in Materials and Methods. *P < 0.05 (n = 10).