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Altered humoral immunity in response to CII in Jnk1−/− and Jnk2−/− mice with CIA indicates a substantial Th1 response in the JNK2-deficient mice. A: Total CII-specific IgG serum levels in wt, Jnk1−/−, and Jnk2−/− mice on day 30 after immunization. IgG1 (B) and IgG2a (C) levels in wt, Jnk1−/−, and Jnk2−/− mice were measured on day 30 after immunization. *P < 0.05 (n = 10).
