Figure 6.

Divergent roles of JNK1 and JNK2 in the development of serum-induced arthritis. Clinical arthritis in wt, Jnk1^−/−, and Jnk2^−/− mice after injection of K/BxN serum i.p., as described in Materials and Methods. A: The mice were assessed for arthritis development by clinical index score and ankle thickness. B: wt BMMs were grown in culture, as described in Materials and Methods, and i.v. injected via tail vein into Jnk1^−/− mice 1 day before and 1 and 3 days after serum transfer. The values represent the mean ± SEM. *P < 0.05 compared with A (wt mice) or B (mice not receiving BMMs under parallel conditions).