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. 2011 Oct;179(4):1667–1680. doi: 10.1016/j.ajpath.2011.06.009

Figure 3.

Figure 3

A Th2 inflammation gene set is shared and correlated in lung airway biopsies of human asthma and a rhesus asthma model. A: Each gene in a previously defined human asthma epithelial three-gene set is increased in rhesus asthma biopsies. Microarray signal ratios for periostin (Agilent probe ID A_24_P347411), CLCA1 (Agilent probe ID A23_P153185), and serpinB2 (Agilent probe ID A_23_P51217) are expressed as mean ± SD. *P < 0.05 versus nonsensitized animals, t-test. B: A previously defined human asthma biopsy 79-gene set is correlated in human and rhesus asthma (Pearson's correlation coefficient ρ = 0.495; P = 4.5 × 10−7). The fold change for each of 93 Agilent probes corresponding to 79 uniquely annotated genes is compared for human Th2-high asthma (versus Th2-low asthma and healthy controls) and rhesus asthma (versus nonsensitized animals). Each point corresponds to one probe, but for clarity only a subset of the 93 probes is labeled.