Figure 4.

Human asthma Th2 inflammation genes are also up-regulated in rhesus and mouse models of asthma. Thirty-five genes that represent a Th2 inflammation signature in the Th2-high subset of human asthma, defined by applying filters of a fold change >1.2 and a q-value of <0.05 to whole-genome expression profiles of lung airway biopsies from the Th2-high subset of asthmatic patients (comparing the Th2-high asthma subset with both the Th2-low asthma subset and the healthy control subjects), were tested for differential expression in the rhesus asthma model and an OVA-induced mouse asthma model. The fold change of each gene in each model species that meets a false discovery rate cutoff of 20% is plotted against the fold change of that gene in human Th2-high asthma. The fold change of rhesus and mouse asthma model genes that do not meet the false discovery rate cutoff is plotted as 1.0.