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. 2011 Oct;179(4):2028–2041. doi: 10.1016/j.ajpath.2011.06.006

Figure 1.

Figure 1

Afferent fibers with potential for sprouting persist after PP lesioning. A–D: Staining for NF at 7 days post lesion demonstrates the NF+ fibers in intact contralateral dentate gyrus (A and C) and the reduced amount of NF+ fibers in the outer molecular layer (oml) of the deafferented ipsilateral (IP) dentate gyrus (B and D). The NF+ fibers that persist in the outer molecular layer may represent calretinergic and cholinergic afferent fibers and other afferent fibers not part of the PP. E and F: Fluoro-Jade staining of the dentate gyrus at 7 days post lesion. The anterograde axonal and terminal degeneration is visualized as an intense band of green fluorescence in the deafferented outer molecular layer in the ipsilateral dentate gyrus (E). No degeneration is observed in the contralateral dentate gyrus (F). CL, contralateral layer; g, granule cell layer; iml, inner molecular layer; ml, molecular layer. Scale bars: 20 μm (C and D); 150 μm (A, B, E, and F).