Figure 1.

Generation of Vpr animals that have two (Agt⁺/Agt⁺), three (Agt^dup/Agt⁺), or four (Agt^dup/Agt^dup) functional copies of the angiotensinogen (Agt) gene at its normal chromosomal location. Since Tetop/Vpr and Podocin/rTTA mice were on the FVBN background, we have used the Agt^dup FVBN congenic strains. *Animals were generated such that the animals used for the breeding were homozygous for the Tetop/Vpr or Podocin/rTTA transgene. **Animals were generated such that the animals used for the breeding were hemizygous for the Tetop/Vpr or Podocin/rTTA transgene.