Vpr-Agt-4 displayed progressive renal lesions despite being off doxycycline (protocol C). A: Renal cortical sections of Vpr-Agt-4, Vpr-Agt-3, and Vpr-Agt-2 were scored for the severity of glomerular lesions. Vpr-Agt-4 showed advanced glomerular lesions when compared with Vpr-Agt-2 and Vpr-Agt-3. *P < 0.01 compared with respective focal segmental glomerulosclerosis (FSGS) of Vpr-Agt-2 and Vpr-Agt-3; **P < 0.01 compared with respective global glomerulosclerosis (GGS) of Vpr-Agt-2 and Vpr-Agt-3; ***P < 0.05 compared with respective collapsing glomerulosclerosis (CGS) of Vpr-Agt-2. B: Renal cortical sections of Vpr-Agt-4, Vpr-Agt-3, and Vpr-Agt-2 were scored for the severity of tubular lesions. Vpr-Agt-4 showed advanced tubular lesions when compared with Vpr-Agt-2. *P < 0.05 compared with Vpr-Agt-2, 2+; **P < 0.05 compared with Vpt-Agt-2, 3+; ***P < 0.05 compared with Vpr-Agt-2, microcyst.