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. 2011 Oct;179(4):1681–1692. doi: 10.1016/j.ajpath.2011.06.013

Figure 7.

Figure 7

Vpr-Agt-4 showed the activation of the RAS. A: Renal cortical sections of Vpr-Agt-2 and Vpr-Agt-4 mice were immunolabeled for renin and angiotensinogen. Representative microphotographs from a Vpr-Agt-2 and a Vpr-Agt-4 mouse are shown. Both glomerular and tubular cells from Vpr-Agt-4 mice displayed greater expression of renin as well as angiotensinogen (indicated by brown staining). Tubular cell expression of renin and angiotensinogen is indicated by black and white arrows, respectively. Glomerular cell expression of angiotensinogen is indicated by a white arrowhead. B: Total RNA was extracted from renal cortical tissues of Vpr-Agt-2 and Vpr-Agt-4 mice from the protocol C, and real-time PCR studies were carried to measure Agt, renin, and ACE expression. *P < 0.001 compared with the respective Vpr-Agt-2; **P < 0.01 compared with respective Vpr-Agt-2.