Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Potential mechanisms of celastrol-mediated protection against aminoglycoside-induced hair cell death. Aminoglycoside antibiotics result in increased ROS production and pro-apoptotic JNK activation in hair cells. Celastrol activates the Nrf2-transcription factor and induces HSP32/HO-1. HSP32/HO-1 inhibits pro-apoptotic JNK activation and hair cell death, possibly through the action of CO
