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Probabilities of distinct configurations of the release site with two channels per vesicle. Denoting the open channel probability by po, the probability that neither channel is open is P(0)=(1–po)2, whereas the probability of one open channel is P(1)=2po(1– po), and the probability of both channels being open is P(2)=po2. Modified from Matveev et al. (2009).
