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Cooperativity and reliability with 2 proximal and 6 distal channels per release site. (A) The distal channels are located at a distance of 90 nm from a release site, while the proximal channel distance is varied. The mobile buffer concentration is 200 μM and the channel opening probability is po=0.5. (B) The Ca2+ current and channel cooperativities increase as the proximal channels are moved away from the release site.
