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. 2011 Aug 5;30(17):3607–3619. doi: 10.1038/emboj.2011.268

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Copyright © 2011, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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The QA ion binding site in TREK-1. TPenA is shown docked into the KvAP-based homology model of TREK-1. Two different side-view images are shown each with one pore-forming unit removed for clarity. The side chains of residues which affect TPenA inhibition are highlighted. Those predicted to directly interact with TPenA are show in green while those which do not appear to contribute directly to the binding site are shown in orange. The right hand panel shows a snapshot of the movie (Supplementary data), which shows a side view of how TPenA (yellow) docks well into the predicted binding site. Residues that affect TPenA block are shown in green. Coordinates for this model are provided in Supplementary data.