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The selectivity filter is involved in pH gating of TREK-1. (A) Activation of TREK-1 channels by indicated intracellular pH, note the small blockage of the current by pH 4.0. (B) Similar experiment for the T157C mutant in P1. (C) Summary of the EC50 values for pH activation of mutations in P1/P2 region of TREK-1 compared with WT channels that is indicated by the dashed line (see Supplementary Figure S5).
