| Lack of neurodegenerative lesions |
+++++ |
| (eg, Alzheimer changes) |
|
| Lack of gliosis |
++++ |
| Smaller cortical and hippocampal pyramidal neurons |
+++ |
| Decreased cortical and hippocampal synaptic markers |
+++ |
| Decreased dendritic spine density |
++ |
| Loss of neurons from dorsal thalamus |
++ |
| Abnoramlities of white matter neurons |
+ |
| Entorhinal cortex dysplasia |
+ |
| Disarray of hippocampal neuron orientation |
+/- |
| Loss of hippocampal or cortical neurons |
0 |
|
0: no good evidence; +/-: equivocal data; 4- to +++++: increasing amounts of supportive data. |
