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| - Which of the cytoarchitectural and synaptic alterations are robust? |
| - Is there a single pathology or several? |
| - How are the structural and neurochemical findings related? |
| - Does the neuropathology underlie the aberrant functional connectivity? |
| - Does the neuropathology relate to psychotic symptoms or the cognitive deficits? |
| - Are the changes diagnostically specific? |
