Table I. Partial list, of selected mutant, genes that cause monogenic neurological disorders.

Gene	Disease	Mapping	Cloning
HD	Huntington chorea	1983	1993
ATI	Ataxia-telangiectasia	1988	1995
SCN4A	Hyperkalemic periodic paralysis	1990	1991
VHL	Von Hippel-Lindau syndrome	1988	1993
DRPLA	Dentatorubral-pallidoluysian atrophy	1993	1993
SMN1	Spinal muscular atrophy	1990	1995
SOD1	Amyotrophic lateral sclerosis, familial	1991	1993
PS1	Alzheimer's disease, early-onset	1992	1995
PS2	Alzheimer's disease, early-onset	1995	1995
FA	Friedreich ataxia	1988	1996
PARK2	Parkinson's disease, juvenile	1997	1998