Figure 4. Estrogen receptor-α(ERα) is critical in estradiol-mediated protection of the brain following stroke injury. Estradiol (E) reduces ischemic infarct in both wildtype mice, WT1 (A) and WT2 (B), compared with corresponding oil-treated controls (n=6-10/group) (*P<0.02). Estradiol fails to protect in ERα knock-out (ERαKO) mice, compared with oil-treated controls (n=1 3/group) (A), but continues to protect in (B) ERβKO mice, compared with oil-treated controls (n=8-9/group) (*P<0.02). Values represent means±SE. Reproduced from reference 140: Dubai DB, Zhu B, Yu B, et al. Estrogen receptor-ot, not -3, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci U S A. 2001;98:1952-1957. Copyright © 2001, National Academy of Sciences, USA.
