Table I. Sensitivity and specificity of clinical measurements. AD, Alzheimer's disease; CERAD, CERAD (Consortium to Establish a Registry for Alzheimer Disease) probable or definite AD (neuropathology); Other, other neuropathological review; DSM-III-R, Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition; NINCDS, National Institutes of Neurological, Communicative Disorders and Stroke.

	No. AD subjecte	No. controls	Clinical criteria	Sensitivity	Specificity	Neuropathological criteria
Boller et al,20 1989	39	15 other	NINCDS probable AD	0.95	0.33	Other
Hoffman et al,15 2000	9	13 other	NINCDS probable AD	0.64	0.88	CERAD
Jobst et al,14 1998	80	38 other	NINCDS probable AD	0.49	1.00	CERAD
Jobst et al,19 1998	80	38 other	DSM-III-R	0.51	0.97	CERAD
Kazee et al, 1993	94	29 normal	NINCDS probable AD	0.98	0.69	Other
Lim et al,16 1999	84	36 other	NINCDS probable AD	0.83	0.55	CERAD
Massoud et al,17 2000	25	36 other	NINCDS probable AD	0.86	0.50	CERAD
Nagy et al,18 1998	46	27 other	NINCDS probable AD	0.41	1.00	CERAD
Nagy et al,18 1998	46	27 other	DSM-III-R	0.39	0.96	CERAD
Tierney et al,21 1988	22	35 other	NINCDS probable AD	0.86	0.89	Other