Table II. Sensitivity and specificity of computed tomography measures. AD, Alzheimer's disease; CERAD, CERAD (Consortium to Establish a Registry for Alzheimer Disease) probable or definite AD (neuropathology); NINCDS, NINCDS (National Institutes of Neurological, Communicative Disorders and Stroke) probable AD (clinical); MTL, mesial temporal lobe; PTC, parietotemporal cortex; rCBF, regional cerebral blood flow; M, measurement; I, impression.
No. AD subjects | No. controls | Measurement/impression | Sensitivity | Specificity | Diagnostic criteria | |
Jebst et al,14 l998 | 200 | 119 normal | (M) MTL width | 0.85 | 0.78 | CERAD |
Jobst et al,14 1998 | 200 | 119 normal | (M) MTL width | 0.80 | 0.93 | CERAD |
(I) PTC rCBF | ||||||
Denihan et al,28 2000 | 60 | 40 other | (M) MTL width | 0.75 | 0.90 | NINCDS |