Figure 2. Neurophysiological studies of the P50 sensory gating phenomena have implicated the pyramidal neurons of the hippocampus as a source of the wave. Interneurons in the hippocampus are responsible for inhibition of pyramidal neuron response in the conditioning-testing or paired stimulus paradigm. These interneurons are excited by cholinergic innervation via α7-nicotinic cholinergic receptors and inhibited by adrenergic receptors. GABA, γ-aminobutyric acid.
