Figure 2. Signal transduction cascade; potential candidate genes for mechanisms of antidepressant action. NE, norepinephrine; 5-HT, 5-hydroxytryptamine (serotonin); R, G-protein-coupled receptor; Gαβγ, G-protein-Gαβγ complex; AC, adenylylcyclase; PLC, phospholipase C; cAMP, cyclic adenosine monophosphate; PKA/PKC, protein kinase A/C; pCREB, phosphorylated cAMP response element-binding (protein); BDNFGen, brain-derived neurotrophic factor gene.
