Figure 2. Meta-analysis of DRD3 risk allele (gly) among seven of the groups included in the pooled analysis reported by Lerer et al6 (the African-American group was excluded because of skewed distribution) and three other published studies.7-9 The size of each plot is proportional to the sample size of each group. The Mantel-Haenszel pooled odds ratio (OR) is =1.33 (95% confidence interval [CI] 1.04-1.70) and the associated test of OR=1 is significant (X2=5.12, df=1, P=0.02), while the cumulative pooled OR is 1.52 with z=11.78 and P<0.0001. The heterogeneity X2=16.97, df=9, P=0.049. Reproduced from reference 6: Lerer B, Segman RH, Fangerau, et al. Pharmacogenetics of tardive dyskinesia: Combined analysis of 780 patients supports association with dopamine D3receptor gene ser9gly polymorphism. Neuropsychopharmacology. 2001;27:109-119. Copyright © Nature Publishing Group 2001.
