Table II. Logistic regression predicting tardive dyskinesia including background, clinical, and genetic variables. PANSS, Positive and Negative Syndrome Scale; CI, confidence interval. *102TT genotype is reference category. Significant values highlighted in bold font.
Variable | β | SE | Wald | df | P | Odds ratio | 95.0% CI | |
Lower | Upper | |||||||
Background variables | ||||||||
Age | 0.04 | 0.02 | 3.93 | 1 | 0.047 | 1.04 | 1.00 | 1.08 |
Sex | 0.20 | 0.49 | 0.16 | 1 | 0.686 | 1.22 | 0.47 | 3015 |
Cigarette-smoking | 0.14 | 0.46 | 0.09 | 1 | 0.766 | 1.15 | 0.47 | 2.83 |
Clinical variables | ||||||||
PANSS total score | 0.02 | 0.01 | 6.00 | 1 | 0.014 | 1.02 | 1.00 | 1.03 |
Age at first antipsychotic treatment | 0.05 | 0.03 | 2.37 | 1 | 0.124 | 1.05 | 0.99 | 1.11 |
Genetic variables | ||||||||
DRDS gly9 allele | 1.48 | 0.54 | 7.61 | 1 | 0.006 | 439 | 1.54 | 12.56 |
HTR2A 102C genotype | 8.80 | 2 | 0.012 | |||||
HTR2A 102CC genotype* | 1.43 | 0.63 | 5.20 | 1 | 0.023 | 4.18 | 1.22 | 14.26 |
HTR2A 1027TC genotype* | -020 | 0.54 | 0.14 | 1 | 0.71 | 0.82 | 0.28 | 2.37 |
MNSOD ala9 allele | -0.39 | 0.51 | 0.58 | 1 | 0.445 | 0.68 | 0.25 | 1.83 |
HTR2A ser23 allele | -0.94 | 0.53 | 3.13 | 1 | 0.077 | 0.39 | 0.14 | 1 11 |
Constant | -5.61 | 1.53 | 13.41 | 1 | 0 | 0 |