Table 3 . Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) ranking of targets. AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; GABA, γ-aminobutyric acid; NMDA, N-methyl-D-aspartate.
Target | Ranking |
α7-Nicotinic receptor agonists | 1 |
Dopamine D1 receptor agonists | 2 |
AMPA glutamatergic receptor agonists | 3 |
α2-adrenergic receptor agonists | 4 |
NMDA glutamatergic receptor agonists | 5 |
Metabotropic glutamate receptor agonists | 6 |
Glycine reuptake inhibitors | 7 |
M1 muscarinic receptor agonists | 8 |
GABAA R subtype selective agonists | 9 |