Table 3 . Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) ranking of targets. AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; GABA, γ-aminobutyric acid; NMDA, N-methyl-D-aspartate.
| Target | Ranking |
| α7-Nicotinic receptor agonists | 1 |
| Dopamine D1 receptor agonists | 2 |
| AMPA glutamatergic receptor agonists | 3 |
| α2-adrenergic receptor agonists | 4 |
| NMDA glutamatergic receptor agonists | 5 |
| Metabotropic glutamate receptor agonists | 6 |
| Glycine reuptake inhibitors | 7 |
| M1 muscarinic receptor agonists | 8 |
| GABAA R subtype selective agonists | 9 |