Table IV. Controlled studies of pharmacotherapy of seasonal affective disorder (SAD).^62-66 LT, light therapy.

Authors	Number of patients	Medication and study design	Outcome
MCGrath et al,⁶² 1990	n=13	L-Tryptophan and LT	No significant difference
		versus L-tryptophan alone
Ruhrmann et al,⁶³ 1998	n=40	Fluoxetine versus LT	No significant difference
			but faster onset of antidepressant
			action in LT group
Ghadirian et al,⁶⁴	n=13	L-Tryptophan versus LT,	No significant difference
		crossover study
Gloth et al,⁶⁵ 1999	n=15	Vitamin D versus LT	Vitamin D superior to LT
Wheatley, ⁶⁶ 1999	n=168	Hypericum and LT	Significant improvement in both
		versus hypericum alone	groups, improvement in sleep greater
			in hypericum and LT group

Table IV. Controlled studies of pharmacotherapy of seasonal affective disorder (SAD).62-66 LT, light therapy.