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. 2004 Mar;6(1):71–77. doi: 10.31887/DCNS.2004.6.1/mackenheil

Table I. Reasons for nonresponse to treatment.

Different etiologies
Duration of untreated psychosis (DUP)
Pharmacokinetic aspects
  • Poor metabolism

  • Ultrarapid metabolism

  • Drug-drug interactions

  • Permeability of the blood-brain barrier

Variations in candidate genes