Figure 3. Polymorphic spectra of candidate genes.80 The genomic reference sequences are presented as baseline, exonic sequences as gray or white (untranslated regions [UTRs]) bars; sequences were drawn to scale, which is indicated. All gene variants are specified by nucleotide variations (substitutions, insertions, and deletions) according to the mutation nomenclature. Candidate genes had been subjected to systematic comparative sequencing. A. The human .-opioid receptor gene (OPRMT), about 6.7 kb, in 250 individuals.29 B. The human β1;-adrenergic receptor gene (ADRB1), about 2 kb, in about 80 individuals.81 C. The human β2-adrenergic receptor gene (ADRB2), about 3 kb, in 515 individuals.70 D. The human CB1 cannabinoid receptor gene (CNR1), about 1.6 kb, in about 200 individuals.62 E. The human promelanin concentrating hormone gene (PMCH), about 1.2 kb, in 141 individuals. Reproduced from reference 80: Hoehe MR, Timmermann B, Lehrach H. Human inter-individual DNA sequence variation in candidate genes, drug targets, the importance of haplotypes and implications for pharmacogenomics. Curr Pharm Biotechnol. 2003;4:351-378. Copyright (c) 2003, Bentham Science Publishers.
