Figure 3. A single restraint stress does not suppress cell proliferation. Repeated restraint stress for 21 days suppresses cell proliferation. Repeated restraint stress for 42 days reduces volume of the dentate gyrus (DG) and the number of neurons in the DG.
Reproduced from reference 51 with permission: Pham K, Nacher J, Hof PR, McEwen BS. Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. Eur J Neurosci. 2003;17:879-886. Copyright © 2003, Biackwell Publishing, Inc.